This is default featured slide 1 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 2 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 3 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 4 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 5 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

Tuesday, January 17, 2023

Going smoke-free in 2023? Medication doubles your odds of success

Daria Kulkova, iStock/Getty Images Plus
By Audrey Darville
University of Kentucky

Most people who smoke attempt to quit at least once a year, so it’s no surprise that quitting smoking is one of the most popular New Year’s resolutions year after year.

If you plan to quit in 2023, there are support tools available that can set you up for success, including medications that can help minimize uncomfortable withdrawal symptoms and cravings when trying to quit.

Studies show that using cessation medicines can double your chances of successfully quitting.

There are three different types of medications approved by the FDA to help you quit smoking — the first is nicotine replacement therapy (NRT), which includes gum, lozenges, patches, inhaler and nasal spray. The other two, bupropion, and varenicline, do not contain nicotine and also help people stop smoking and reduce cravings.

If you have tried using NRT to quit before but it didn’t seem to help, you may want to talk to your health care provider about other forms of NRT, varenicline or bupropion.

Varenicline works differently than other quit-smoking medicines by attaching to the same parts of your brain that are stimulated by nicotine, reducing the urge to smoke. It also makes smoking less pleasurable by blocking some of nicotine’s effects. Bupropion helps people quit smoking by decreasing craving and other nicotine withdrawal symptoms. We now know that combining NRT patches and gum or lozenges is more effective than using one form alone.

Most people need NRT or take varenicline or bupropion for 12 weeks. Your health care provider might prescribe it for longer, if needed.

Talk to a health care provider to get a prescription for varenicline, bupropion or an NRT inhaler. Your doctor will review your medical history to help determine the right prescription for you, and discuss how to use it safely.

Cessation medications are affordable for most Kentuckians. Medicaid and many health insurance plans cover FDA-approved quit-smoking medicines, including varenicline and bupropion.

In addition to medications, counseling is another accessible treatment strategy that increases your likelihood of success. In Kentucky, the free quitline 1-800-QUIT-NOW provides personalized coaching to help you quit tobacco for good.

If you’ve tried quitting before, don’t be discouraged and don’t give up! It can take around 10 attempts to quit for good. Quitting is the most important thing you can do to improve your health and quality of life.

Sunday, January 15, 2023

Dietitian says even 10% weight loss has health benefits; weight-loss drugs, diets and pediatric guidelines are in the news

American Heart Association photo
By Melissa Patrick
Kentucky Health News

As the end of January approaches and that New Year's resolution to lose weight may have already been forgotten, it's important to remember that if you are overweight, it's worth the effort to hang onto that resolution. Even losing up to 10 percent of your body weight can provide health benefits. 

Karen Klefot, registered dietitian and diabetes consultant at the Barnstable Brown Diabetes Center at the University of Kentucky, told Kentucky Health News that it's important for a person to set short-term goals when they are trying to lose weight and that even a 10% weight loss can improve blood pressure, sleep, cholesterol and energy levels.  

"There is value in losing up to 10 percent of an individual's weight," Klefot said. "Oftentimes, we feel like we have to lose 50 pounds, but . . . that's a lot of weight, when really, honestly, you know, we can have those health benefits with it only being 10 percent."

Klefot offered several suggestions for getting started with a weight-loss plan, including keeping track of your daily exercise and daily food intake as a way to evaluate where some lifestyle changes can be made. 

"I think it's important to focus on things that are realistic and attainable, especially when it comes to weight loss," she said, later adding, "And I would say to focus on one to two pounds per week." 

For example, she said one easy lifestyle change is to trade sugar-sweetened beverages for water or to add more fiber-rich foods, fruits, vegetables and whole grains to the diet. And, she said, eat less fast food, which takes some planning ahead.    

Asked about the popular low-carbohydrate diets, Klefot stressed that it's important to not cut out carbohydrates completely because they are the main fuel source for our bodies. 

"We're not supposed to be depriving our body of carbs," she said. Also, "We need healthy fat and we need protein."

Further, she said it's important to limit sweet treats to "every now and then, but maybe not every single day." And if you have a strong sweet tooth, try adding more fruit to your diet. 

Klefot also noted that increasing your physical activity is important for weight loss, noting that the general recommendation is for a person to get 150 minutes of moderate-intensity aerobic activity a week. The Centers for Disease Control and Prevention adds two or more days of muscle-strengthening activities a week to that recommendaton. 

MyPlate.gov is the federal government's guide to healthy eating.
Recognizing that insurance does not always cover weight-loss efforts, Klefot encouraged people to look at reliable sources when it comes to seeking solutions, such as MyPlate.gov, the U.S. Department of Agriculture's guide to healthy eating. In addition, she encouraged yearly physicals and said localthe  health department often offers diabetes programs. 

"I wish more insurances would cover more appointments with a registered dietitian because I think more patients would be able to come," which would likely reduce both obesity and diabetes in Kentucky," Klefot said. 

Best diets in 2023

Each year U.S. News & World Report reviews a list of science-backed diets and ranks them. The diets are reviewed by a panel of leading medical and nutrition specialists in diabetes, heart health and weight loss. 

Of the 24 diets that were reviewed, the Mediterranean diet ranked first. This diet focuses on plant-based foods, like fruits and vegetables, while incorporating whole grains, beans, nuts, seafood, lean poultry and unsaturated fat from extra-virgin olive oil.

The DASH diet, which stands for dietary approaches to stop hypertension, or high blood pressure, tied for second place. It also emphasizes fruits, vegetables, whole grains, lean protein and low-fat dairy, which are high in blood pressure-lowering nutrients, like potassium, calcium, magnesium and fiber.

Also tied for second was the flexitarian diet, a semi-vegetarian diet that allows a person to be a vegetarian most of the time, but to still be able to enjoy meat on a special occasion. 

New weight-loss guidelines for children

For the first time in 15 years, the American Academy of Pediatrics has released new evidence-based recommendations for treating childhood obesity, with an emphasis on early and intensive treatment. 

The new guidelines stress that obesity is a chronic disease and should be treated as such. And while the guidelines continue to say that intensive behavioral therapy and lifestyle changes should be a first-line approach, for the first time AAP now recommends children 12 and older be considered for anti-obesity medications and those 13 and older with severe obesity be considered for weight-loss surgery. 

“There is no evidence that ‘watchful waiting’ or delayed treatment is appropriate for children with obesity,” Dr. Sandra Hassink, an author of the guideline and vice chair of the Clinical Practice Guideline Subcommittee on Obesity, said in an AAP news release.

NBC News reports that there are now four drugs approved for obesity treatment in teens starting at age 12: "Orlistat, Saxenda, Qsymia and Wegovy — and one, phentermine, for teens age 16 and older. Another drug, called setmelanotide (brand name Imcivree), has been approved for kids age 6 and older who have Barde-Biedl syndrome, a genetic disease that causes obesity."

In Kentucky, 39% of children were either overweight or obese in 2019-20, up from 37% in 2016-2017, according to the 2022 Kids Count Data Book. The State of Childhood Obesity report says that in 2020-2021, 25.5% of Kentucky's children were obese. 

New anti-obesity drugs are expensive

The Trust for America's Health latest annual report says four of every 10 Kentucky adults are obese and 72.3% are either obese or overweight, ranking the state third in the nation.

New drug treatments for obesity are working, but they are expensive and are not always covered by health insurance, Lesley Stahl reported Jan. 1 on CBS's "60 Minutes." 

One of those drugs is semaglutide, marketed under the brand Ozempic for Type 2 diabetes and Wegovy, in higher doses, for weight loss. CBS reports Ozempic was first approved by the Food and Drug Administration as a type 2 diabetes medication in 2017. Wegovy was approved by the FDA as a chronic weight management treatment in 2021.

In support of these medications, Dr. Fatima Cody Stanford, an obesity doctor at Massachusetts General Hospital and associate professor at Harvard Medical School, told Stahl that the common beliefs about obesity are all wrong. It's not willpower, she said, "It's a brain disease. And the brain tells us how much to eat and how much to store." Further, she said, "The number one cause of obesity is genetics." 

Doctors are frustrated that there are drugs that works for obesity, but insurance companies won't cover them. 

"We are frustrated every single day when we see patients who desperately need to lose weight to reduce diabetes, reduce the hypertension, stroke, heart disease, and we can't give them this fabulous, robust medication that is very effective and safe. And we can't give it to them because insurance won't cover it," Dr. Caroline Apovian, co-director of the Weight Management and Wellness Center at Brigham and Women's Hospital in Boston, told Stahl. 

In Kentucky, Ozempic and Wegovy are not covered by Medicaid for weight loss. Stahl reported that  Rhode Island officials have decided that health insurance for their state employees will cover the entire class of anti-obesity drugs.

NBC News reports that experts are confident that the FDA will likely approve Eli Lilly & Co.'s drug tirzepatide for weight loss in 2023, but it also will be expensive and there is little indication that insurers will widely cover it. 

Lilly declined to comment on the new drug's cost, but NBC reports, "Outside experts said it is possible the drugmaker could price it similarly to Wegovy, which carries a list price of around $1,500 for a month’s supply, and Saxenda, which costs about $1,350 for a month’s supply."

Study: If you're obese or diabetic, and get over 20% of calories from fast food, you're more likely to get a deadly liver disease

Photo from WomenFitness.net
People who are obese or diabetic and get 20 percent or more of their calories from fast food are more likely to get non-alcoholic fatty liver disease, a potentially life-threatening condition, says a new study from the University of Southern California.

The study, published in the peer-reviewed journal Clinical Gastroenterology and Hepatology, "gives people extra motivation to reduce fast-food consumption," a USC news release said. The study found that beyond the obese and diabetic, "The general population has moderate increases of liver fat when one-fifth or more of their diet is fast food."

“Even a moderate increase in fat can lead to non-alcoholic fatty liver disease,” said  Dr. Ani Kardashian, a USC hepatologist and lead author of the study. “The severe rise in liver fat in those with obesity or diabetes is especially striking, and probably due to the fact that these conditions cause a greater susceptibility for fat to build up in the liver.”

Obesity and diabetes are big health issues in Kentucky. The state ranks first in obesity among childen aged 10 to 17, third in percenatge of the population considered obese, and seventh in percentage with diabetes.

Earlier research has shown links between fast food and obesity and diabetes, but this is one of the first studies to demonstrate the negative impact of fast food on the liver, Kardashian said.

“If people eat one meal a day at a fast-food restaurant, they may think they aren’t doing harm,” said Kardashian. “However, if that one meal equals at least one-fifth of their daily calories, they are putting their livers at risk.”

Nonalcoholic fatty liver disease, also known as liver steatosis, can lead to cirrhosis, or scarring of the liver, which can cause liver cancer or failure, USC says. Liver steatosis affects over 30% of the U.S. population.

The study was based on the nation’s largest annual nutrition poll, the National Health and Nutrition Examination Survey. It characterized fast food as meals, including pizza, from either a drive-through restaurant or one without wait staff. It looked at about 4,000 adults whose fatty-liver measurements were included in the survey and compared these measurements to their fast-food consumption.

"Of those surveyed, 52% consumed some fast food. Of these, 29% consumed one-fifth or more daily calories from fast food. Only this 29% of survey subjects experienced a rise in liver fat levels," USC says.

"The association between liver steatosis and a 20% diet of fast food held steady for both the general population and those with obesity or diabetes even after data was adjusted for multiple other factors such as age, sex, race, ethnicity, alcohol use and physical activity."

Kardashian said, “Our findings are particularly alarming, as fast-food consumption has gone up in the last 50 years, regardless of socioeconomic status. We’ve also seen a substantial surge in fast-food dining during the Covid-19 pandemic, which is probably related to the decline in full-service restaurant dining and rising rates of food insecurity. We worry that the number of those with fatty livers has gone up even more since the time of the survey.”

Kardashian said she hopes the study will encourage health-care providers to offer patients more education about nutrition, especially to those with obesity or diabetes ,who are at higher risk of developing a fatty liver from fast food. The only known way to treat liver steatosis is through an improved diet.

Friday, January 13, 2023

University of Kentucky researchers find Covid-19 vaccinations and boosters protects mothers and babies

Ilhem Messaoudi, chair of the University of Kentucky
College of Medicine's Department of Microbiology,
 Immunology and Molecular Genetics.
Mark Cornelison | UK Photo.
By Lindsay Travis
University of Kentucky

University of Kentucky researchers have found that maternal vaccination against COVID-19 works to protect both the mother and baby.

The study, funded by a National Institutes of Health grant, was published in the American Journal of Obstetrics and Gynecology Maternal-Fetal Medicine. The findings come as COVID-19 cases and hospitalizations are on the rise across the U.S. and the Commonwealth after the holidays.

“COVID-19 is here to stay. It’s not going anywhere," said Ilhem Messaoudi, Ph.D., chair of the Department of Microbiology, Immunology and Molecular Genetics in the UK College of Medicine. "The study shows that vaccines are safe and maternal vaccinations are an effective way to protect not only the mom but the baby until they become eligible for the vaccine. We don’t think that you can fully protect the baby by just breastfeeding.”

Messaoudi and her team at UK conducted the study in collaboration with Oregon Health & Science University.

Researchers monitored a cohort of 120 women from March 2021 until June 2022, through pregnancy, delivery and postpartum, plus two rounds of COVID-19 vaccinations and their booster shot. Roughly 90% of participants received Pfizer’s vaccine.

“What we’ve learned is the first series of the vaccine induces a pretty good immune response in the moms that we can track by looking at antibodies in their plasma,” said Messaoudi.

Scientists monitored antibody response in blood samples from the mother, umbilical cord and newborn along with donated breast milk from the vaccinated participants. Researchers found that antibodies passively transfer from mother to fetus in utero, offering the most protection.

“So at birth, these babies had maternal antibodies in circulation, which is fantastic. Getting vaccinated during pregnancy not only protected the mom, but also now provided passive protection for their newborns who are not eligible for the vaccine,” said Messaoudi.

In this study, the participants received their boosters after giving birth. Within a couple of weeks, researchers saw a dramatic increase in antibodies in the mother’s plasma, which were not directly passed to newborns at the time. But the antibodies in breast milk increased two- to three-fold, Messaoudi said, with a half-life of more than 200 days.

“There was a massive increase in antibodies, which was unexpected but great to see,” said Messaoudi. “You really needed the first two shots and the booster to achieve excellent protection, to have that very long-lived, durable immune response. Then the newborn is protected via antibody transfer in utero through the placenta and postnatal through breastfeeding.”

The Centers for Disease Control and Prevention recommends everyone 6 months and older get the COVID-19 vaccine, including people who are pregnant, breastfeeding, trying to get pregnant now or might become pregnant in the future.

People who are pregnant or were recently pregnant, are more likely to get severely ill from COVID-19 compared to people who are not pregnant, according to the CDC, and have a higher risk for preterm birth.

“Pregnancy is a state of immunosuppression to facilitate the growth and development of a fetus. That’s why it’s even more important that pregnant women get vaccinated,” said Messaoudi.

The immunologist explained it’s the first step in a mother giving potentially lifesaving help to their child, like putting on an oxygen mask while on a plane before you help others.

“Not only is it important to get vaccinated, but it's important to go through the whole series of vaccinations because we also know from the study that just getting the first two shots is not going to be enough. You have to get your booster and the Omicron bivalent booster so that you can get the full benefit,” said Messaoudi.

Researchers will continue to monitor study participants and expect to release more findings on the boosters’ efficacy against the omicron variant in the continued fight against COVID-19.

“We now have a really large number of studies on vaccinations in pregnant women,” said Messaoudi. “They’ve all shown great safety, tolerability and immunogenicity, so we’ve hit the trifecta. The vaccines are safe and work. That’s what’s really important.”

Messaoudi told Travis that there were "no adverse outcomes" in the study, adding that every time a mother came in to give a breastmilk sample they also did a nasal swab to check for Covid-19. In addition, she said they got samples from the babies.

"We had very, very few breakthrough infections," she said. "It was great to see that. It’s doing what it’s supposed to be doing.”
   




Kentucky's child-vaccination rates are sixth worst in the nation

Choreograph, iStock /  Getty Images Plus
By Melissa Patrick
Kentucky Health News

When it comes to influenza and Covid-19 vaccinations, Kentucky's children are less protected than children in other states.   

Kentucky's children have the sixth lowest rate of vaccination against Covid-19 and influenza, with only 38% having received a Covid-19 vaccine and only 35% having a flu shot. That's much lower than the national rates of 57% and 55% respectively, according to a Quote Wizard report. 

Dr. Sean McTigue, medical director for pediatric infection and control at UK HealthCare, said in an e-mail that while most cases of Covid-19 and flu in children are mild to moderate and can be managed at home, they do see young patients who experience serious complications from these respiratory illnesses. 

"The best way to prevent serious illness from these viruses is through vaccinations," McTigue said. "This year’s flu vaccine is a very good match with the predominantly circulating strain of influenza, which makes it very effective. Additionally, the current Covid-19 bivalent booster is still showing good efficacy against the Omicron variant and its subvariants, which are currently the strains in wide circulation.”

The report adds that when people aren't vaccinated, it exposed those around them to additional risks, especially those with underlying conditions. 
Covid-19 vaccinations; Kentucky Department for Public Health chart

The researchers found that older children are more likely to be vaccinated than younger children. This certainly held true in Kentucky, where 25% of its 5-12-year-old population and 50% of its 12-to-17-year-old population are vaccinated. 

State reports break the Covid-19 vaccination numbers down a bit differently, but also show that older children are more likely to be vaccinated in Kentucky. The data shows only 5% of children under 4 have received the first dose of the Covid-19 vaccine; 25% of children 5-11; 50% of children 12-15; and 54% of children 16-17. 

Quote Wizard used data from the Centers for Disease Control and Prevention and the American Academy of Pediatrics to determine the vaccine rates in each state. Data were compiled in the last week of December 2022.


Wednesday, January 11, 2023

Black Kentuckians need more information about colon cancer screening, especially the availability of in-home tests, study finds

Most focus-group participants had not been offered
 stool-based testing as an option for colorectal cancer
 screening, stressing the need for more community-
based outreach. (Photo by fizkes, iStock/Getty Images Plus)
By Elizabeth Chapin
University of Kentucky

A recent study at the University of Kentucky's Markey Cancer Center highlights the need for increased outreach and education to reduce colorectal cancer screening disparities in Black communities.

According to the study, published published in the Journal of Cancer Education, people in Kentucky’s Black communities may not be aware of all of the colorectal-cancer screening options available to them, particularly stool-based tests.

Black communities are disproportionately affected by colorectal cancer. In Kentucky, Blacks who have colorectal cancer are more likely to die from the disease than whites.

Since about half of the racial gap can be explained by differences in screening rates, educating Black communities about screening options can save lives, says Markey Cancer Center researcher Aaron Kruse-Diehr, the study’s principal investigator.

“In the colorectal-cancer screening world, we like to say ‘the best test is the one a patient completes’ — and giving people multiple options has been shown in previous studies to increase their likelihood of completing screening,” said Kruse-Diehr, who is an associate professor in the UK College of Medicine. “To reduce the Black-white colorectal cancer mortality rate, we need to make sure Black people of screening age are being provided all available options.”

Regular screening, beginning at age 45 is the key to preventing colorectal cancer and finding it early. Two types of tests are recommended by the U.S. Preventive Services Task Force: visual exams (primarily colonoscopies) and tests that check a stool sample for signs of cancer. Stool-based tests are less invasive and, for many, more accessible since they can be done at home.

Kruse-Diehr said, “Home tests can reduce a number of both individual-level and structural barriers that often exist for many people with respect to completing colonoscopy, such as needing to take time off work, finding an individual to drive the person to/from the procedure, and travel distance to a provider who can perform colonoscopy.”

The research team partnered with five Black churches in Louisville, which has bihg racial differences in screening, to conduct focus groups exploring screening barriers and facilitators for cancer education and outreach.

While focus-group participants overwhelmingly recognized the importance of being up to date with screening, nearly all reported that they had never heard about stool-based tests or heard health-care providers offer them as an option.

To address this knowledge gap, participants stressed community-based outreach and communication from trusted individuals, such as local Black medical providers and colorectal cancer survivors.

Kruse-Diehr led the study with Elizabeth Holtsclaw, cancer support strategic partnerships manager at the American Cancer Society. Two of the study’s co-authors, College of Public Health undergraduates Carlee Combs and Rose Wood, helped analyze the data and write the results as part of an independent-study course.

The research team is now planning to pilot a church-based screening program with one of the partner churches, with hopes of eventually expanding the program across Kentucky.

“These study results are informing outreach efforts that we hope will make a huge dent in the death rates from colorectal cancer among Black Kentuckians,” said Kruse-Diehr.

Monday, January 9, 2023

Covid-19 cases up nearly 76% in Ky.; hospital numbers inched up

New York Times chart, adapted by Ky. Health News; to enlarge, click on it; to download, right-click.
By Melissa Patrick
Kentucky Health News

Kentucky reported a nearly 76 percent increase in new coronavirus cases last week, and hospital numbers inched up.

The state Department for Public Health's latest weekly report showed 6,208 new cases of Covid-19, or 886 per day. That's up 75.76% from the week prior when the state reported 3,532 new cases. Nearly 7% of the new cases, or 425 of them, were in people 18 or younger.

The share of Kentuckians testing positive for the coronavirus is 11.78%, down almost a full percentage point from 12.74% the week prior. These numbers do not reflect at-home testing.

Covid-19 hospital numbers rose, but not as much as the week before. Kentucky hospitals reported 491 patients with the disease, up 11 from a week earlier, with 73 in intensive care (up 15) and 26 on mechanical ventilation (up 2). 

The weekly new-case incidence rate was 14.67 cases per 100,000 residents, nearly the same as the prior week's 14.6. The top 10 counties were Bath, 35.4 cases per 100,000; Clinton, 35; Caldwell 32.5; Boyd, 32.1; Greenup,31.3; Lewis, 29.1; Harlan, 28.6; Cumberland, 28.1; Perry, 27.2; and Carlisle, 27.

The New York Times ranks Kentucky's infection rate 17th among the states, with a 12% decrease in cases in the last two weeks. 

The state attributed 37 more deaths to Covid-19 last week, up from 27 the week before. Kentucky's pandemic death toll is 17,734.