This is default featured slide 1 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 2 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 3 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 4 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

This is default featured slide 5 title

Go to Blogger edit html and find these sentences.Now replace these sentences with your own descriptions.This theme is Bloggerized by Lasantha Bandara - Premiumbloggertemplates.com.

Tuesday, June 4, 2024

The science of sunscreens: Sorting out advice and rumors

Slip on a shirt, slop on sunscreen, slap on a hat, seek shelter, slide on sunglasses (YLE illustration)
By Katelyn Jetelina
Your Local Epidemiologist

Summer is here! While sunscreen may seem like an easy health decision, many people, especially younger and health-conscious ones, have doubts. Sunscreen health advice and rumors are everywhere on social media, and we’re seeing it reflected in national surveys:
So, what’s going on with sunscreen? With the help of many people, including Dr. Michelle Wong, an Australian cosmetic chemist, I went down a rabbit hole. Ultimately, it comes down to a general lack of scientific nuance in sunscreen discussions and differing risk tolerance.

Here’s what we know about sunscreen, what we don’t know, and what it may (or may not) mean to you.

First, skin cancer is bad. It is the fifth most common cancer in the U.S. While rates have steadily increased over the past few decades, recent years may suggest rates are plateauing. We don’t know why, but some have attributed it to a new awareness of sun protection, including reducing tanning-bed use.
New cases and deaths from melanoma of the skin over time (National Cancer Insitute, annotated by YLE)
Is sunscreen effective against skin cancer? Yes. But this is hard to study.

Theoretically and at a microscopic level, sunscreen makes sense. It stops burns and prevents microscopic changes from accumulating over time that eventually cause cancer.

When we look at “real world” studies among humans, though, there is mixed evidence of sunscreen’s effectiveness against cancer. Two recent meta-analyses that pooled all these studies found no effect. However, sunscreen use is notoriously hard to measure—many other things could explain the link (i.e., confounders), it takes time to see an impact on cancer, and there is variability in how people use sunscreen.

Australian study of sunscreen effect on skin cancer (Graph from YLE; study discussed below)
If we pull out the most rigorous studies (randomized controlled trials, or RCTs) that followed people over a long period of time, there is a consistent positive effect:
  • A well-conducted RCT of adult Australians was followed for more than 15 years and found a 40% lower incidence (876 vs. 996 per 100,000) of cancer among participants randomized to daily sunscreen compared with participants assigned to use sunscreen on a discretionary basis.
  • Some populations are at higher risk of skin cancer, mainly because the medications they take make them more susceptible. Among organ transplant recipients—some of the highest-risk people for skin cancer—studies have found sunscreen prevented cancer.
Is sunscreen effective against photoaging? This is a clear yes. Evidence from many studies and different populations, including a large RCT, shows that sunscreen prevents signs of photo-aging, including wrinkles and pigmentation.
 
Do-it-yourself sunscreens don’t work for two reasons:
  • Sunscreen developers use special grades of zinc oxide with very small particles, which absorb more UV and can cover a larger area. These powders are also often coated to improve dispersion, while DIY recipes usually specify “uncoated” powders.
  • Even with the right ingredients and equipment, sunscreen formulators must optimize the formula extensively to achieve consistently high SPF—sunscreens are considered one of the hardest products to create!
What about the safety of ingredients? Safety is always important; we must ensure benefits continue to outweigh the risks on a population level. A lot has happened regarding sunscreen ingredients in the past few years:
  • FDA studies. In 2019, FDA conducted safety studies on four specific ingredients. Public concern escalated after 2019 and 2020 randomized controlled studies confirmed that common sunscreen ingredients, like oxybenzone, were found in the bloodstream. In 2021, the FDA stated two out of 16 ingredients (zinc oxide and titanium dioxide) were considered safe, two were unsafe (thankfully, these aren’t included in U.S. market sunscreens), and the rest needed more data.
  • Sunscreen contaminants caused a recall. In 2021 and 2022, a private lab found traces of benzene—a chemical that causes cancer—in some sunscreens. Importantly, benzene was a contaminant, not a sunscreen ingredient.
  • Continued research on sunscreen ingredients. Some independent studies have found links between chemical sunscreen ingredients and hormone and reproductive function.
Are these safety signals enough to change population-level behavior? The scientific consensus is “no” given three reasons:
  • Most are lab or animal studies. Petri dishes (bacteria, cells, yeast) and animal studies (rats, fish, etc.) differ from ours, so these studies must be interpreted cautiously.
  • Dose determines the poison. Animal studies often use very high doses, administered orally. With the right dosage and route of exposure, anything can be a poison, even water.
  • Human studies suggest correlation vs. causation. One human study, for example, linked sunscreen ingredients to hormone disrupters in children, but the link was correlational—even the authors stated that many other things could explain the relationship. Another study found more than 96% of people had oxybenzone in their urine. However, fewer than 96% of people use sunscreen, suggesting other environmental sources contribute to levels. Multiple systematic reviews of human studies have concluded there is no support for sunscreen causing infertility, differing hormone levels, body fat, kids’ growth, or cancer.
In other words, just because we can measure something doesn’t necessarily mean it’s harmful. It does suggest that more studies should be done.

The FDA has requested manufacturers test the 12 ingredients with “insufficient evidence,” but there’s a problem: The FDA’s requirements would violate animal-testing bans. So, these older sunscreens may be removed from the US market, even though they are widely used and considered safe in other regions like the European Union, Australia, Japan, and Korea, alongside newer sunscreen ingredients unavailable to Americans (more on the complex regulatory situation here).

In the EU, as a precaution, they have lowered the allowed percentages of a few ingredients, particularly homosalate and oxybenzone. “Unsafe” in the EU means there isn't a 100-fold margin of safety with daily full-body application. These regulatory changes are small shifts to improve the safety of already safe products on a population level.
 
The health policy in the U.S. holds strong: Sunscreen’s known benefits outweigh the unclear risks. Will this change over time? It's possible, but it’s worth noting that the oldest chemical sunscreen ingredients have been used extensively worldwide for over 40 years without clear health risks emerging.

Population-level consensus can be different from individual-level decision-making, though. I still use sunscreen every morning and grab whatever I can for my family while rushing to the beach. Of all the risks we face every day, sunscreen is a very small one to me.

But everyone’s risk tolerance is different. For those who are more hesitant, the good news is that there are options:
  • Concerned about effectiveness? Whether you're using sunscreen or not, layers are the name of the game. The Covid-19 Swiss cheese model applies to sun protection.
  • Concerned about unclear risks? Check the ingredient list—luckily, many different sunscreen formulas are available.
  • Concerned with sunscreen being white cast or heavy? There are two types of sunscreens. A “chemical sunscreen” is likely more suitable for you.
  • Concerned with skin sensitivity or oiliness? A “mineral sunscreen” is more suitable.
Overall, keep in mind:
  • “Broad spectrum” sunscreen is best. The SPF rating on American sunscreen bottles mostly denotes a sunscreen’s ability to block UVB rays. Importantly, these are the most damaging type—they cause burning, skin cancer, and premature skin aging. Some sunscreens in the U.S. don’t cover UVA rays well. Sunscreens labeled "broad spectrum" have a better UVA/UVB protection balance.
  • Higher SPF gives higher protection. You may have seen that SPF 50 blocks 98% of UV while SPF 30 blocks 97%, so there's only a 1% difference. However, this is only true if you apply the correct amount perfectly evenly, which is impossible. If the same amount is applied, SPF 30 will always let 1.67 times more UV than SPF 50.
  • Vitamin D can still reach the skin. High SPF sunscreens are designed to filter out UVB rays, the exact type of rays needed to produce vitamin D in our bodies. However, sunscreen doesn’t filter out all of these rays, and sunscreen application is uneven because humans are humans. Many studies show that people who use sunscreen daily can maintain their vitamin D levels. We also get Vitamin D from food sources.
Bottom line: Sunscreen can help fight skin cancer and prevent photo-aging. Given how difficult sunscreen is to study, there are some unclear risks. Uncertainty can be uncomfortable, so it’s unsurprising that there is much contradicting information about sunscreen (and really anything in health). The good news is that options exist, and the best type of sunscreen is one that you will use.

Fauci, facing Congress for first time since retirement, distances himself from aide who used personal emails for business

Dr. Anthony Fauci (Photo by Francis Chung, Politico)
Kentucky Health News

Dr. Anthony Fauci defended his actions during the Covid-19 pandemic before House lawmakers Monday and distanced himself from an aide accused of misconduct, Politico's Carmen Paun reports.

Fauci pushed back on claims by Republicans on the House Select Subcommittee on the Coronavirus Pandemic that he tried to squelch the theory that the virus spilled over from a lab in Wuhan, China.

Fauci said that the theory isn’t a conspiracy theory, and that he has kept an open mind on the pandemic's origins, but has endorsed a theory that the disease came from an animal.

He said the research his agency funded at the lab couldn’t have created Covid. The Department for Health and Human Services has stripped the EcoHealth Alliance, the U.S. research group that collaborated on virus studies with Wuhan, and its president of federal funding.

Fauci, 83, was director of the National Institute of Allergy and Infectious Diseases from 1984 to 2022, and chief medical adviser to President Biden from 2021 to 2022

Democrats and Republicans on the panel recently blasted longtime Fauci adviser David Morens, whom HHS put on leave for using personal email for official business. Emails the subcommittee released last month show Morens trying to shield correspondence.

In his first public Capitol Hill testimony since leaving the federal government, Fauci said Morens wasn’t part of his inner circle. “Despite his title, and even though he was helpful to me in writing scientific papers, Dr. Morens was not an adviser to me on institute policy or other substantive issues,” Fauci said.

Monday, June 3, 2024

New website helps Kentuckians find mental-health treatment; has had 5,000 first-time users since it launched in March

The site is part of FindHelpNow.org, which also serves Tenenssee.
By Stephanie Ramsey
University of Kentucky

Despite growing awareness of mental-health issues, many people still struggle to find the right resources and treatment for mental health. The journey to receiving care can be confusing and overwhelming due to limited information on available services, long wait times and geographical barriers.

To address these challenges, the Kentucky Injury Prevention and Research Center has introduced an extension of its FindHelpNowKY.org website to include a dedicated website for mental health, FindMentalHealthNowKY.org. The new resource portal provides information on mental-health treatment options, helping to bridge the gap between those seeking help and the providers that offer it.

"This revamp is about breaking down the barriers to mental health care and making it easier for people to find the support they need. The new FindMentalHealthNowKY.org is a critical resource that offers near-real-time information on treatment options, reducing the stress and uncertainty that often come with seeking help," said KIPRC Director Terry Bunn.

FindMentalHealthNowKY.org was created by KIPRC as an agent for the state Department for Public Health in partnership and with funding from with the Department for Behavioral Health, Developmental and Intellectual Disabilities, both in the Cabinet for Health and Family Services.

The new website offers a comprehensive array of mental-health services designed to meet the diverse needs of its users. If someone is seeking individual or group counseling, the platform provides curated list of licensed therapists and counselors. For those requiring more intensive care, the site connects users with inpatient treatment facilities and hospitals equipped to handle more complex mental health conditions. The range of options ensures that individuals can find the right level of care, whether dealing with everyday stress or facing more challenging concerns.

Since its launch in March 2024, FindMentalHealthNowKY.org has seen significant engagement, with over 5,000 first-time users. Notably, more than 36% of these users have specifically been searching for mental health resources, indicating a significant demand for information and support in this area.

“Accessibility and convenience are key,” said FindMentalHealthNowKY Program Manager Catherine Hines. “FindMentalHealthNowKY.org provides a simple, user-friendly interface, allowing visitors to quickly locate the information they need. The prompt updates allow users to find openings for counseling, inpatient treatment or crisis intervention without the frustration of outdated or inaccurate information."

In addition to treatment options, FindMentalHealthNowKY.org is launching a comprehensive resource library on mental health topics. The library will contain thousands of entries, providing an extensive collection of information and support. These educational resources offer guidance on a variety of topics, empowering users to make informed decisions about their mental health.

One of the biggest barriers to seeking mental health support is the stigma associated with mental health issues. "Our goal is to provide reliable, accurate information that helps break down the stigma surrounding mental health,” Bunn said. “By offering comprehensive resources and educational materials, we aim to make it easier for people to seek help and encourage open conversations."

FindMentalHealthNowKY.org helps break down barriers by offering accessible, up-to-date and trustworthy resources. Its extensive resource library of educational materials foster a more open and understanding approach to mental health. If you're seeking mental health resources or support, visit FindMentalHealthNowKY.org.

Sunday, June 2, 2024

UK has a new group to research infectious diseases, including treatment and prevention through community engagement

By Lindsay Travis
University of Kentucky

A new partnership between researchers at the University of Kentucky will combat the threat of infectious diseases through research directed at prevention and treatment.

The CURE-KY team: Front row left to right: Vincent Venditto,
Steven Van Lanen, Ilhem Messaoudi, Rebecca Dutch. Back
row: Feng Li, David Burgess, Beth Garvy, Richard Greenberg.
Not pictured: Krystle Kuhs. (UK photo by Jeremy Blackburn)
The Consortium for Understanding and Reducing Infectious Diseases in Kentucky (CURE-KY) will foster multidisciplinary collaborations to address the burden of infectious diseases in the state and beyond.

“I am thrilled by the boundless possibilities our collaborative efforts promise at the University of Kentucky,” said Ilhem Messaoudi, founder of CURE-KY and chair of the Department of Microbiology, Immunology, and Molecular Genetics in the College of Medicine. “With a steadfast commitment to advancing knowledge and fostering transdisciplinary alliances, we aim to propel infectious-disease research to new heights, creating a healthier Kentucky and nurturing future scientific leaders.”

She added, “We have an excellent team of scientists here at UK and on our leadership team. Together we can tackle infectious diseases from an array of perspectives to make a difference in the health of our community.”

CURE-KY grew from, and took most of its acronym from, UK’s Covid-19 Unified Research Experts Alliance. It has experts from the College of Medicine, College of Public Health, College of Pharmacy, Martin-Gatton College of Agriculture, Food and Environment and the Markey Cancer Center.

It will focus on research in five areas: microbial pathogenesis; vaccines, therapeutics and antimicrobial resistance; public health and community engagement; animal health; and engineering and systems. IT will also work to address vaccine hesitancy and misinformation to foster trust between Kentuckians and the scientific community.

“From studying prevention, control and understanding transmission dynamics to assessing risk, promoting health equity and engaging communities in disease-control efforts, this work is critical toward our goal of creating a healthier Kentucky,” said Public Health Dean Heather Bush.

Dr. B. Mark Evers, Markey director, said “Kentucky is home to the highest cancer rates in the country, including several cancers caused by infectious diseases such as HPV and hepatitis C. . . . By better understanding and combating diseases that can lead to cancer, CURE-KY will contribute to this mission and make progress toward our ultimate goal of conquering cancer in the commonwealth.”

More information about CURE-KY and upcoming events is on on its website.

Dr. Wendell Kingsolver, a doctor for more than half a century and an advocate for family medicine and rural health, dies at 96

Wendell Kingsolver, M.D.
Dr. Wendell Roy Kingsolver, a longtime physician and advocate for family medicine and public health, especially in rural Kentucky, died Thursday, May 30. He was 96 and lived in Nicholasville.

After graduation from the University of Kentucky and an internship and residency, Kingsolver set up a family practice at Carlisle in his home Nicholas County. He was one of the few physicians in the area and served patients of all ages at all hours in emergency, operating, and delivery rooms, He was among the first physicians certified by the American Board of Family Practice, and trained UK medical students in rural family practice as they lived in his home and learned what a diverse rural medical career was like. In the 1960s he was a medical volunteer in the Republic of Congo, and later on the Caribbean island of St. Lucia and the Newfoundland coast town of St. Anthony. After retiring from five decades of full-time private practice, he was a public-health doctor for the Wedco District Health Department in in Nicholas, Harrison, Bourbon and Scott counties.

Kingsolver was an early adopter of organic farming, and he and his first wife Virginia were founding members of the Sierra Club chapter in Kentucky, the group that built Lake Carnico in Nicholas County, and the First Christian Church in Carlisle, where he was an elder and sang in the choir. He was a board member of the Cane Ridge Meeting House, where the Disciples of Christ denomination began. He enjoyed birdwatching and served a term as president of the Kentucky Ornithological Society. He and Ginny, who predeceased him, established a KOS scholarship for young people interested in the study of birds, and worked to preserve natural land in Nicholas County, some of it donated to the Blue Licks Battlefield State Resort Park.

Kingsolver's survivors include his wife, Eva Lee (Lynam Kanatzar) Kingsolver; son Robert (Paula) Kingsolver; daughter and noted author Barbara Kingsolver (Steven Hopp); and Ann Kingsolver, former director of the Appalachian Center at UK. A viewing will be held Tuesday, June 4, at 2 p.m., followed by the funeral at 4 p.m., at Milward Funeral Home, 391 Southland Drive in Lexington.

Information for this article was taken from the obituary.

Ky. Hospital Association presents awards at annual convention

Nina Eisner (KHA photos)
Kentucky Health News

The Kentucky Hospital Association honored several health-care leaders in the state at its annual convention in Lexington on May 21.

KHA’s highest honor, the Distinguished Service Award, was presented to Nina Eisner and Charles Lovell for untiring and exceptional service.

Eisner has served in clinical and administrative health-care positions for 45 years. In 2002, she became CEO of The Ridge Behavioral Health System in Lexington, She has been a strong advocate for Kentucky’s psychiatric hospitals and their patients and is a long-serving KHA trustee and has served in many other roles with KHA, the association said in a news release.

Charles Lovell
Lovell has been part of the Kentucky and Tennessee health-care landscape for the past 45 years. After serving as an emergency-room nurse in Memphis, he became CEO of several Tennessee and Kentucky hospitals, coming to Kentucky in 2003, to run Caldwell County Hospital in Princeton. He helped build a replacement hospital to serve Caldwell and Lyon counties.

In 2015, Lovell became community CEO at Barbourville ARH Hospital, which added many services and was the 2023 Knox County Chamber of Commerce Business of the Year. Lovell himself was the chamber's Man of the Year. Lovell has also held many roles with the KHA, chairing its Board of Trustees in 2013-14.

KHA’s Award of Excellence, given to individuals who have made significant contributions to health care in Kentucky, was presented to State Rep. Danny Bentley, R-Russell. 

Bentley, a pharmacist, has represented House District 98 (Greenup County and part of Boyd County) since 2017. He is known for helping his neighbors with health issues, and as a legislator helped pass measures that helped rural hospitals.

The KHA Health Care Governance Leadership Award, for individuals who have had a positive and sustainable impact on the quality of care in their communities through their work as hospital trustees, was presented to Gavin Roberts, chair of the Owensboro Health Board of Directors. The hospital is Owensboro’s largest employer, and Roberts has chaired the Owensboro Chamber of Commerce.

First naxolone shipment under settlement with drug maker arrives

Kentucky Health News

Nearly 8,000 doses of naloxone, which reverses the effects of drug overdose, were delivered to Kentucky this week as part of a settlement with Teva Pharmaceuticals, Attorney General Russell Coleman announced.

In October, Teva agreed to pay the state more than $71 million over 13 years, resolving allegations that the company’s marketing and promotional practices fueled the opioid-overdose crisis. In addition to the cash payments, Teva agreed to provide more than 23,000 units of naloxone.

The shipment, the first of four expected this year, went to facilities in Louisville, Florence, Ashland, Paducah and Frankfort. The Opioid Commission is partnering with the Cabinet for Health and Family Services as well as the Kentucky Pharmacists Association for distribution.

“Naloxone is a critical lifeline for Kentucky families struggling with addiction,” Coleman said in a news release. “Equipping first responders, health professionals and treatment providers with this all-important medication can help save lives for Kentuckians on the road to recovery.”

Half of all opoid-settlement funds go to local governments. The state's half is distribited by the Kentucky Opioid Abatement Advisory Commission is responsible for the distribution, part of the attorney general's office. On Tuesday, June 4,, the commission will award its next round of grants.

Kentuckians can find out how to get free naloxone near them at FindNaloxoneNowKY.org. Naloxone is also sold under the brand name Narcan by Emergent Solutions Inc.